Pesquisa | BVS Violência e Saúde

1.

KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport.

Schmick, Malte; Vartak, Nachiket; Papke, Björn; Kovacevic, Marija; Truxius, Dina C; Rossmannek, Lisaweta; Bastiaens, Philippe I H.

Cell ; 157(2): 459-471, 2014 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-24725411

2.

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins.

Rocks, Oliver; Gerauer, Marc; Vartak, Nachiket; Koch, Sebastian; Huang, Zhi-Ping; Pechlivanis, Markos; Kuhlmann, Jürgen; Brunsveld, Lucas; Chandra, Anchal; Ellinger, Bernhard; Waldmann, Herbert; Bastiaens, Philippe I H.

Cell ; 141(3): 458-71, 2010 Apr 30.

Artigo em Inglês | MEDLINE | ID: mdl-20416930

3.

Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis.

Ghallab, Ahmed; González, Daniela; Strängberg, Ellen; Hofmann, Ute; Myllys, Maiju; Hassan, Reham; Hobloss, Zaynab; Brackhagen, Lisa; Begher-Tibbe, Brigitte; Duda, Julia C; Drenda, Carolin; Kappenberg, Franziska; Reinders, Joerg; Friebel, Adrian; Vucur, Mihael; Turajski, Monika; Seddek, Abdel-Latief; Abbas, Tahany; Abdelmageed, Noha; Morad, Samy A F; Morad, Walaa; Hamdy, Amira; Albrecht, Wiebke; Kittana, Naim; Assali, Mohyeddin; Vartak, Nachiket; van Thriel, Christoph; Sous, Ansam; Nell, Patrick; Villar-Fernandez, Maria; Cadenas, Cristina; Genc, Erhan; Marchan, Rosemarie; Luedde, Tom; Åkerblad, Peter; Mattsson, Jan; Marschall, Hanns-Ulrich; Hoehme, Stefan; Stirnimann, Guido; Schwab, Matthias; Boor, Peter; Amann, Kerstin; Schmitz, Jessica; Bräsen, Jan H; Rahnenführer, Jörg; Edlund, Karolina; Karpen, Saul J; Simbrunner, Benedikt; Reiberger, Thomas; Mandorfer, Mattias.

J Hepatol ; 80(2): 268-281, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-37939855

4.

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation.

Bloch, Denise; Diel, Patrick; Epe, Bernd; Hellwig, Michael; Lampen, Alfonso; Mally, Angela; Marko, Doris; Villar Fernández, María A; Guth, Sabine; Roth, Angelika; Marchan, Rosemarie; Ghallab, Ahmed; Cadenas, Cristina; Nell, Patrick; Vartak, Nachiket; van Thriel, Christoph; Luch, Andreas; Schmeisser, Sebastian; Herzler, Matthias; Landsiedel, Robert; Leist, Marcel; Marx-Stoelting, Philip; Tralau, Tewes; Hengstler, Jan G.

Arch Toxicol ; 97(11): 3005-3017, 2023 11.

Artigo em Inglês | MEDLINE | ID: mdl-37615677

5.

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells.

Nell, Patrick; Kattler, Kathrin; Feuerborn, David; Hellwig, Birte; Rieck, Adrian; Salhab, Abdulrahman; Lepikhov, Konstantin; Gasparoni, Gilles; Thomitzek, Antonia; Belgasmi, Katharina; Blüthgen, Nils; Morkel, Markus; Küppers-Munther, Barbara; Godoy, Patricio; Hay, David C; Cadenas, Cristina; Marchan, Rosemarie; Vartak, Nachiket; Edlund, Karolina; Rahnenführer, Jörg; Walter, Jörn; Hengstler, Jan G.

J Hepatol ; 77(5): 1386-1398, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-35863491

6.

On the Mechanisms of Biliary Flux.

Vartak, Nachiket; Drasdo, Dirk; Geisler, Fabian; Itoh, Tohru; P J Oude Elferink, Ronald; van de Graaf, Stan F J; Chiang, John; Keitel, Verena; Trauner, Michael; Jansen, Peter; Hengstler, Jan G.

Hepatology ; 74(6): 3497-3512, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34164843

7.

Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion-Dominated Canalicular and Flow-Augmented Ductular Bile Flux.

Vartak, Nachiket; Guenther, Georgia; Joly, Florian; Damle-Vartak, Amruta; Wibbelt, Gudrun; Fickel, Jörns; Jörs, Simone; Begher-Tibbe, Brigitte; Friebel, Adrian; Wansing, Kasimir; Ghallab, Ahmed; Rosselin, Marie; Boissier, Noemie; Vignon-Clementel, Irene; Hedberg, Christian; Geisler, Fabian; Hofer, Heribert; Jansen, Peter; Hoehme, Stefan; Drasdo, Dirk; Hengstler, Jan G.

Hepatology ; 73(4): 1531-1550, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-32558958

8.

Liver specific, systemic and genetic contributors to alcohol-related liver disease progression.

Schnabl, Bernd; Arteel, Gavin E; Stickel, Felix; Hengstler, Jan; Vartak, Nachiket; Ghallab, Ahmed; Dooley, Steven; Li, Yujia; Schwabe, Robert F.

Z Gastroenterol ; 60(1): 36-44, 2022 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-35042252

9.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Ghallab, Ahmed; Hofmann, Ute; Sezgin, Selahaddin; Vartak, Nachiket; Hassan, Reham; Zaza, Ayham; Godoy, Patricio; Schneider, Kai Markus; Guenther, Georgia; Ahmed, Yasser A; Abbas, Aya A; Keitel, Verena; Kuepfer, Lars; Dooley, Steven; Lammert, Frank; Trautwein, Christian; Spiteller, Michael; Drasdo, Dirk; Hofmann, Alan F; Jansen, Peter L M; Hengstler, Jan G; Reif, Raymond.

Hepatology ; 69(2): 666-683, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30102412

10.

Small molecule inhibition of the KRAS-PDEÎ´ interaction impairs oncogenic KRAS signalling.

Zimmermann, Gunther; Papke, Björn; Ismail, Shehab; Vartak, Nachiket; Chandra, Anchal; Hoffmann, Maike; Hahn, Stephan A; Triola, Gemma; Wittinghofer, Alfred; Bastiaens, Philippe I H; Waldmann, Herbert.

Nature ; 497(7451): 638-42, 2013 May 30.

Artigo em Inglês | MEDLINE | ID: mdl-23698361

11.

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.

Albrecht, Wiebke; Kappenberg, Franziska; Brecklinghaus, Tim; Stoeber, Regina; Marchan, Rosemarie; Zhang, Mian; Ebbert, Kristina; Kirschner, Hendrik; Grinberg, Marianna; Leist, Marcel; Moritz, Wolfgang; Cadenas, Cristina; Ghallab, Ahmed; Reinders, Jörg; Vartak, Nachiket; van Thriel, Christoph; Golka, Klaus; Tolosa, Laia; Castell, José V; Damm, Georg; Seehofer, Daniel; Lampen, Alfonso; Braeuning, Albert; Buhrke, Thorsten; Behr, Anne-Cathrin; Oberemm, Axel; Gu, Xiaolong; Kittana, Naim; van de Water, Bob; Kreiling, Reinhard; Fayyaz, Susann; van Aerts, Leon; Smedsrød, Bård; Ellinger-Ziegelbauer, Heidrun; Steger-Hartmann, Thomas; Gundert-Remy, Ursula; Zeigerer, Anja; Ullrich, Anett; Runge, Dieter; Lee, Serene M L; Schiergens, Tobias S; Kuepfer, Lars; Aguayo-Orozco, Alejandro; Sachinidis, Agapios; Edlund, Karolina; Gardner, Iain; Rahnenführer, Jörg; Hengstler, Jan G.

Arch Toxicol ; 93(6): 1609-1637, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-31250071

12.

Reply.

Vartak, Nachiket; Hengstler, Jan G.

Hepatology ; 75(2): 493-494, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34546585

13.

Reply.

Vartak, Nachiket; Hengstler, Jan G.

Hepatology ; 75(4): 1061-1062, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-34953145

14.

Reply.

Vartak, Nachiket; Elferink, Ronald Oude; van de Graaf, Stan; Drasdo, Dirk; Hengstler, Jan.

Hepatology ; 76(3): E58, 2022 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-35344603

15.

The ascending pathophysiology of cholestatic liver disease.

Jansen, Peter L M; Ghallab, Ahmed; Vartak, Nachiket; Reif, Raymond; Schaap, Frank G; Hampe, Jochen; Hengstler, Jan G.

Hepatology ; 65(2): 722-738, 2017 02.

Artigo em Inglês | MEDLINE | ID: mdl-27981592

16.

Activated ErbB3 Translocates to the Nucleus via Clathrin-independent Endocytosis, Which Is Associated with Proliferating Cells.

Reif, Raymond; Adawy, Alshaimaa; Vartak, Nachiket; Schröder, Jutta; Günther, Georgia; Ghallab, Ahmed; Schmidt, Marcus; Schormann, Wiebke; Hengstler, Jan G.

J Biol Chem ; 291(8): 3837-47, 2016 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-26719328

17.

REPLY.

Vartak, Nachiket; Hengstler, Jan G.

Hepatology ; 74(2): 1133, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-33559147

18.

Cholestasis-induced adaptive remodeling of interlobular bile ducts.

Vartak, Nachiket; Damle-Vartak, Amruta; Richter, Beate; Dirsch, Olaf; Dahmen, Uta; Hammad, Seddik; Hengstler, Jan G.

Hepatology ; 63(3): 951-64, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26610202

19.

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.

Berg, Valeska; Rusch, Marion; Vartak, Nachiket; Jüngst, Christian; Schauss, Astrid; Waldmann, Herbert; Hedberg, Christian; Pallasch, Christian P; Bastiaens, Philippe I H; Hallek, Michael; Wendtner, Clemens-Martin; Frenzel, Lukas P.

Blood ; 125(19): 2948-57, 2015 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-25670628

20.

The autodepalmitoylating activity of APT maintains the spatial organization of palmitoylated membrane proteins.

Vartak, Nachiket; Papke, Bjoern; Grecco, Hernan E; Rossmannek, Lisaweta; Waldmann, Herbert; Hedberg, Christian; Bastiaens, Philippe I H.

Biophys J ; 106(1): 93-105, 2014 Jan 07.

Artigo em Inglês | MEDLINE | ID: mdl-24411241

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KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport.

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins.

Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis.

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation.

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells.

On the Mechanisms of Biliary Flux.

Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion-Dominated Canalicular and Flow-Augmented Ductular Bile Flux.

Liver specific, systemic and genetic contributors to alcohol-related liver disease progression.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Small molecule inhibition of the KRAS-PDEÎ´ interaction impairs oncogenic KRAS signalling.

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.

Reply.

Reply.

Reply.

The ascending pathophysiology of cholestatic liver disease.

Activated ErbB3 Translocates to the Nucleus via Clathrin-independent Endocytosis, Which Is Associated with Proliferating Cells.

REPLY.

Cholestasis-induced adaptive remodeling of interlobular bile ducts.

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.

The autodepalmitoylating activity of APT maintains the spatial organization of palmitoylated membrane proteins.